Isonicotinonitrile 1-oxide(CAS: 14906-59-3)

Isonicotinonitrile 1-oxide (CAS: 14906-59-3) is a crystalline solid with a molecular weight of approximately 142.13 g/mol. It has a melting point of 116-118°C and is slightly soluble in water. It is reactive towards basic compounds and can undergo hydrolysis. The compound is also prone to decomposition under acidic conditions.

Isonicotinonitrile 1-oxide is typically synthesized by the reaction of isonicotinoyl chloride with hydroxylamine hydrochloride. This process involves the condensation of the amide with a nitrile to form the 1-oxide derivative. The reaction is catalyzed by a base such as triethylamine and occurs in an organic solvent like dichloromethane. The yield is usually around 75-85%.

Isonicotinonitrile 1-oxide (CAS: 14906-59-3) is primarily used in the pharmaceutical and chemical industries for the synthesis of various organic compounds. It finds applications in the development of new drugs and as a precursor in the production of certain polymers. Additionally, it is used in the preparation of chemical sensors and in semiconductor manufacturing processes.

When handling Isonicotinonitrile 1-oxide (CAS: 14906-59-3), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a laboratory coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.