1H-Pyrazol-1-ol(CAS: 81945-73-5)

1H-Pyrazol-1-ol (CAS: 81945-73-5) is a white crystalline solid with a molecular weight of approximately 98.11 g/mol. It is slightly soluble in water and ethanol. Chemically, it is a basic compound and can undergo nucleophilic substitution reactions. It has a pKa of about 6.3.

1H-Pyrazol-1-ol can be synthesized by the reduction of 1H-pyrazole with sodium borohydride in an aqueous medium. Another method involves the reaction of hydrazine with carbon dioxide, followed by hydrolysis. These methods typically yield 1H-Pyrazol-1-ol with good selectivity and moderate to high yield.

1H-Pyrazol-1-ol (CAS: 81945-73-5) is used in the pharmaceutical industry for the synthesis of certain drugs, as a precursor in polymer chemistry for its unique properties, and in the development of sensors and semiconductors due to its electronic characteristics.

When handling 1H-Pyrazol-1-ol (CAS: 81945-73-5), wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Perform reactions in a well-ventilated fume hood to minimize inhalation risk. Proper spill cleanup procedures should be followed, and always consult the safety data sheet (SDS) for detailed guidance on handling and storage.