3-Bromo-5-fluorobenzonitrile(CAS: 179898-34-1)

3-Bromo-5-fluorobenzonitrile (CAS: 179898-34-1) is a crystalline solid with a molecular weight of approximately 217.02 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is highly reactive, particularly towards nucleophiles and electrophiles. It exhibits good reactivity towards reduction and electrophilic aromatic substitution reactions.

3-Bromo-5-fluorobenzonitrile is typically synthesized via nucleophilic substitution reactions. One common method involves the reaction of 5-fluorobenzenecarbonyl chloride with sodium bromide in the presence of a base like potassium carbonate. This process yields high selectivity and good yield, making it a reliable method for industrial synthesis.

3-Bromo-5-fluorobenzonitrile (CAS: 179898-34-1) finds applications in the pharmaceutical industry for the synthesis of various compounds, in the polymer industry as a monomer, and in the semiconductor industry for sensor development. It is also used in research and development for catalyst screening and organic synthesis.

When handling 3-Bromo-5-fluorobenzonitrile (CAS: 179898-34-1), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to avoid inhalation. In case of spillage, immediately clean up with appropriate absorbents and follow standard safety protocols. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.