3-Amino-2-methoxyisonicotinic acid(CAS: 870997-81-2)

3-Amino-2-methoxyisonicotinic acid is a crystalline solid. Its molecular weight is approximately 230.23 g/mol. It is slightly soluble in water but more soluble in solvents like ethanol and methanol. Chemically, it is reactive towards nucleophiles and can participate in condensation reactions. It has a pKa of around 2.5, indicating acidic behavior.

3-Amino-2-methoxyisonicotinic acid can be synthesized by reacting nicotinic acid with methylamine followed by methylation. Alternatively, it can be prepared by the nucleophilic substitution of methoxy group on nicotinic acid. The reaction typically requires a mild base as a catalyst and provides good yield (up to 85%) with high selectivity.

3-Amino-2-methoxyisonicotinic acid finds applications in the pharmaceutical industry for the synthesis of certain drug intermediates. It is also used in the preparation of sensors and may have potential in the semiconductor industry due to its aromatic structure. Additionally, it can be used in polymer chemistry for functionalization purposes.

When handling 3-Amino-2-methoxyisonicotinic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure to vapors. Spills should be immediately cleaned up using appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.