4-Chloro-2(1H)-pyrimidinone(CAS: 80927-55-5)

4-Chloro-2(1H)-pyrimidinone is a yellow crystalline solid with a molecular weight of 133.55 g/mol. It has a pKa of approximately 6.5 and is slightly soluble in water. It is reactive towards nucleophiles and exhibits good stability under normal conditions.

4-Chloro-2(1H)-pyrimidinone can be synthesized by the condensation of chloroformic acid with urea. This reaction typically requires a base catalyst and proceeds with good yield. Other methods include direct chlorination of pyrimidine derivatives or via the Wittig reaction.

4-Chloro-2(1H)-pyrimidinone is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those containing pyrimidine derivatives. It is also used in the polymer industry for the development of specific polymers and in the semiconductor industry for certain electronic applications.

When handling 4-Chloro-2(1H)-pyrimidinone, it is important to use appropriate personal protective equipment (PPE) such as gloves and goggles. It should be stored in a cool, dry place away from direct sunlight and sources of heat. In case of spill, use appropriate spill response equipment and follow local safety regulations.