6-Bromo-1(2H)-isoquinolinone(CAS: 82827-09-6)

6-Bromo-1(2H)-isoquinolinone is a crystalline solid with a molecular weight of approximately 225.03 g/mol. It has a solubility of about 0.01 g/100 mL in water and is soluble in organic solvents like ethanol and acetone. This compound is relatively stable but can react with strong bases. It is soluble in common organic solvents and has a melting point of around 195-197°C.

6-Bromo-1(2H)-isoquinolinone is typically synthesized via bromination of 1(2H)-isoquinolinone. Common methods include using bromine in an appropriate solvent or using N-bromosuccinimide (NBS) as a brominating agent. The reaction is carried out under anhydrous conditions to avoid side reactions. The yield is generally around 70-80%.

6-Bromo-1(2H)-isoquinolinone finds applications in the pharmaceutical industry as an intermediate for drug synthesis. It is also used in the polymer industry for the synthesis of polymers with specific properties. Additionally, it is used in the sensor industry for the development of chemical sensors and in the semiconductor industry for certain electronic applications.

Proper personal protective equipment (PPE) is essential when handling 6-bromo-1(2H)-isoquinolinone, including gloves, goggles, and protective clothing. This compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.