2',3'-O-Isopropylideneguanosine(CAS: 362-76-5)

2',3'-O-Isopropylideneguanosine is a crystalline compound with a molecular weight of approximately 320.46 g/mol. It has a solubility of about 0.2 mg/mL in water. Chemically, it is less reactive than other guanosine derivatives, but it is prone to hydrolysis under acidic or basic conditions. The compound is stable under neutral conditions and in the absence of moisture.

2',3'-O-Isopropylideneguanosine is synthesized through a multistep process starting from guanosine. Commonly, the synthesis involves protection of the 2' and 3' hydroxyl groups using isopropylidene acetic anhydride, followed by deprotection under basic conditions. The key steps include nucleophilic substitution and hydrolysis, with good yield and selectivity.

2',3'-O-Isopropylideneguanosine is primarily used in the pharmaceutical industry for the development of nucleoside analogs for antiviral and anticancer drugs. It is also utilized in the production of nucleic acid analogs for research applications in biotechnology and genomics. Additionally, it has potential applications in the sensor and semiconductor industries due to its unique chemical structure.

When handling 2',3'-O-Isopropylideneguanosine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a fume hood to avoid inhalation or skin contact. Spills should be cleaned up using absorbent materials, and the area should be flushed with water. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.