(1R)-1-[2-(Trifluoromethyl)phenyl]ethanamine(CAS: 127733-46-4)

The (1R)-1-[2-(Trifluoromethyl)phenyl]ethanamine (CAS: 127733-46-4) is a crystalline solid with a molecular weight of approximately 224.12 g/mol. It is sparingly soluble in water but soluble in common organic solvents like ethanol and acetonitrile. The compound is known for its high reactivity towards nucleophilic substitution and electrophilic aromatic substitution reactions.

This compound is usually synthesized via amination of 2-(trifluoromethyl)benzaldehyde with ethylamine, using a catalytic amount of a suitable amine such as triethylamine. The reaction is typically carried out under mild conditions, leading to a high yield of the desired (1R)-isomer.

This compound is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various medicinal compounds. It also finds applications in the polymer industry for the development of specialized polymers and in the sensor industry for the fabrication of gas sensors.

When handling (1R)-1-[2-(Trifluoromethyl)phenyl]ethanamine (CAS: 127733-46-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Ensure the reaction is conducted in a well-ventilated fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials, and the area should be decontaminated. Consult the Safety Data Sheet (SDS) for additional safety information.