(6-Amino-3-pyridinyl)boronic acid(CAS: 851524-96-4)

(6-Amino-3-pyridinyl)boronic acid is a crystalline solid with a molecular weight of approximately 229.13 g/mol. It has a moderate solubility in water (3.1 g/100 mL) and is sparingly soluble in ethanol. The compound exhibits good reactivity, particularly in Suzuki coupling reactions, and demonstrates stability in neutral to slightly acidic conditions.

(6-Amino-3-pyridinyl)boronic acid can be synthesized through a multistep process involving the synthesis of 6-aminopyridine, followed by the formation of the boronic acid ester. Common synthetic methods include the use of boron tribromide or boron trichloride as reagents, with selective protection of functional groups to ensure high yield and purity.

(6-Amino-3-pyridinyl)boronic acid is primarily used in the pharmaceutical industry for the synthesis of drug intermediates, particularly in organic synthesis for the preparation of various biologically active compounds. It is also utilized in the polymer industry for the development of functional polymers and in the semiconductor industry for the fabrication of electronic materials.

When handling (6-Amino-3-pyridinyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. Store the compound in a cool, dry place, away from direct sunlight. Use a fume hood during reactions and disposal. Always consult a Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.