Apixaban Impurity 84(CAS: 14273-86-0)

Apixaban Impurity 84 (CAS: 14273-86-0) is a crystalline solid with a molecular weight of approximately 414.43 g/mol. It has a density of about 1.25 g/cm³ and is slightly soluble in water. The impurity exhibits low reactivity under standard conditions but may undergo hydrolysis under acidic or basic conditions. It is stable at room temperature and pressures but should be stored in a dry, cool place.

Apixaban Impurity 84 (CAS: 14273-86-0) is synthesized through a multistep process involving condensation, oxidation, and purification steps. The synthesis typically uses organic solvents like dichloromethane and water. Catalysts such as sulfuric acid are employed for the initial steps, and the process yields about 85% purity. The final product is isolated via recrystallization and characterized by spectroscopic methods.

Apixaban Impurity 84 (CAS: 14273-86-0) is primarily used in the pharmaceutical industry, particularly for quality control and impurity profiling in the development of apixaban, an anticoagulant drug. It is also relevant in analytical chemistry for the testing of drug formulations and in environmental monitoring to assess the presence of pharmaceuticals in water supplies.

When handling Apixaban Impurity 84 (CAS: 14273-86-0), it is crucial to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably in a fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be washed down. Refer to the safety data sheet (SDS) for detailed information on handling and disposal procedures.