5-Chloro-1,3-dihydro-2H-indol-2-one(CAS: 17630-75-0)

5-Chloro-1,3-dihydro-2H-indol-2-one is a white crystalline solid with a molecular weight of approximately 226.65 g/mol. It has a pKa value of around 3.2 and is slightly soluble in water but more soluble in organic solvents such as methanol and ethanol. The compound shows moderate reactivity towards nucleophiles and electrophiles, and it is stable under acidic and neutral conditions but can degrade under basic conditions.

5-Chloro-1,3-dihydro-2H-indol-2-one can be synthesized via a multi-step process. Common methods include the condensation of chloroacetic acid with indole followed by cyclization. This process typically requires the use of Lewis acids as catalysts and can achieve a yield of around 70-80%. Selectivity towards the desired product can be enhanced by careful control of reaction conditions.

5-Chloro-1,3-dihydro-2H-indol-2-one is primarily used in the pharmaceutical industry for the development of various medicinal compounds. It is also utilized in the sensor technology industry for its potential to detect certain chemical species. Additionally, it can be used in the semiconductor industry for specific applications in materials science.

When handling 5-Chloro-1,3-dihydro-2H-indol-2-one, it is important to use proper personal protective equipment (PPE), such as gloves and safety goggles, to prevent skin and eye contact. It should be stored in a cool, dry place away from sources of heat and ignition. In case of spill, the area should be ventilated, and the spill should be cleaned up with appropriate tools. The safety data sheet (SDS) should be consulted for detailed handling and emergency procedures.