(5-Fluoro-3-pyridinyl)boronic acid(CAS: 872041-86-6)

(5-Fluoro-3-pyridinyl)boronic acid is a white crystalline solid with a molecular weight of approximately 217.1 g/mol. It has a low solubility in water but is more soluble in organic solvents. This compound is known for its reactivity in boronate ester formation and its use in various organic reactions. It is slightly basic in nature due to the presence of the pyridine ring and the boronic acid group.

(5-Fluoro-3-pyridinyl)boronic acid is typically synthesized through the reaction of 5-fluoro-3-pyridineboronic acid with an appropriate base or in the presence of a catalyst. Common methods include Suzuki cross-coupling reactions or direct synthesis from 5-fluoro-3-pyridineboronic acid. The yield is generally high, and the product can be isolated by recrystallization.

(5-Fluoro-3-pyridinyl)boronic acid finds applications in pharmaceuticals, where it is used in drug synthesis as a building block. It is also used in the synthesis of polymers and sensors due to its functional groups. In the semiconductor industry, it is employed in the production of boron-doped materials and as a precursor in materials science research.

When handling (5-Fluoro-3-pyridinyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coat. It should be stored in a dry, well-ventilated area, away from direct sunlight. In the event of a spill, it should be cleaned up using appropriate procedures and materials. Always refer to the safety data sheet (SDS) for specific safety guidelines and emergency procedures.