6-Amino-5-bromonicotinic acid(CAS: 180340-69-6)

6-Amino-5-bromonicotinic acid is a white crystalline solid with a molecular weight of approximately 241.03 g/mol. It is slightly soluble in water and ethanol. Chemically, it is less reactive than its parent compound, nicotinic acid, due to the presence of the amino group and bromine substituent.

6-Amino-5-bromonicotinic acid is typically synthesized by bromination of 6-aminonicotinic acid. This involves the reaction of 6-aminonicotinic acid with bromine in the presence of a base like sodium hydroxide. The reaction is conducted in a polar aprotic solvent such as acetonitrile.

6-Amino-5-bromonicotinic acid is used primarily in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the organic synthesis field, where it is used as an intermediate for the preparation of various compounds.

When handling 6-Amino-5-bromonicotinic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood. Store the compound in a cool, dry place away from direct sunlight and flammable materials. In case of spillage, neutralize the spill with an appropriate acid-base neutralizer and clean up according to standard laboratory safety procedures.