Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate(CAS: 86189-69-7)

Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate is a crystalline compound with a molecular weight of approximately 413.02 g/mol. It has low solubility in water but is more soluble in organic solvents like dichloromethane and acetone. It is moderately reactive, showing some tendency towards hydrolysis and oxidation. The compound is a derivative of pyridine and exhibits typical aromatic properties.

Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate is synthesized using a multi-step procedure involving the condensation of 2,3-dichloroaniline with dimethyl malonate. The reaction is catalyzed by a Lewis acid like aluminum chloride, and yields up to 85% of the target compound. The process involves protecting groups and deprotection steps to achieve the desired product.

Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate finds applications in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used in the polymer industry as a stabilizer and in the semiconductor manufacturing sector for its unique electronic properties. Its presence in chemical sensors and as a photoacid generator in photolithography further expands its industrial uses.

When handling Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn at all times. It should be stored in a fume hood to minimize exposure to vapors. Spills should be immediately contained and cleaned up using appropriate absorbents. In case of accidental ingestion, ingestion should be avoided, and the chemical safety data sheet (SDS) should be consulted for further guidance. Always ensure good laboratory practices and work in a well-ventilated area.