6-amino-2,3-dihydro-1H-inden-1-one(CAS: 69975-65-1)

6-amino-2,3-dihydro-1H-inden-1-one is a white crystalline solid with a molecular weight of approximately 148.17 g/mol. It has a solubility of about 1.2 g/L in water at 20°C. The compound is moderately reactive, showing some tendency towards hydrolysis and reduction. It is soluble in common organic solvents like methanol and acetone.

6-amino-2,3-dihydro-1H-inden-1-one is typically synthesized via a condensation reaction between an indole derivative and an aldehyde or ketone, followed by reduction and deprotection steps. The reaction is catalyzed by palladium(II) acetate and triphenylphosphine, with a yield of around 75%. The process requires careful control of reaction conditions to ensure high selectivity and yield.

6-amino-2,3-dihydro-1H-inden-1-one finds applications in pharmaceuticals, particularly in the synthesis of drugs with specific aromatic and nitrogen functionalities. It is also used in the development of sensors and as a precursor in the manufacturing of certain polymers and semiconductors.

Proper personal protective equipment (PPE) should be worn when handling 6-amino-2,3-dihydro-1H-inden-1-one, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure. In the event of a spill, use absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.