2-Ethoxyethyl 4-methylbenzenesulfonate(CAS: 17178-11-9)

2-Ethoxyethyl 4-methylbenzenesulfonate is a colorless or slightly yellowish liquid with a molecular weight of approximately 250.37 g/mol. It has a melting point of -20 to -18°C, a boiling point of 120-122°C, and is soluble in ethanol, acetone, and methylene chloride. It is reactive towards nucleophiles and can undergo substitution reactions, making it useful in organic synthesis.

2-Ethoxyethyl 4-methylbenzenesulfonate is typically synthesized by reacting 4-methylbenzenesulfonic acid with ethylene oxide, followed by hydrolysis to form the ethoxyethyl ester. This process often uses sodium hydroxide as a catalyst and achieves a yield of around 90%. The reaction is exothermic and requires careful temperature control.

2-Ethoxyethyl 4-methylbenzenesulfonate is used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs) and intermediates. It is also utilized in the polymer industry as a plasticizer and a compatibilizer. Additionally, it finds applications in the manufacturing of sensors and semiconductors due to its solubility and reactivity.

When handling 2-Ethoxyethyl 4-methylbenzenesulfonate, ensure proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation exposure. Store it in a cool, dry place, away from incompatible substances like acids. In case of a spill, use appropriate spill cleanup materials and consult the Safety Data Sheet (SDS) for specific instructions.