2-Bromo-4,6-diphenylnicotinonitrile(CAS: 82127-26-2)

2-Bromo-4,6-diphenylnicotinonitrile is a crystalline solid with a molecular weight of approximately 427.24 g/mol. It is slightly soluble in water but readily soluble in organic solvents like ethanol and acetone. Chemically, it is stable under normal conditions but reacts with reducing agents. It has a pKa of about 13.5 and can be used as a functional group in organic synthesis.

2-Bromo-4,6-diphenylnicotinonitrile is typically synthesized via a reaction between 4,6-diphenylnicotinonitrile and bromine in the presence of a catalyst such as iron(III) bromide. The reaction is carried out in an inert solvent like dichloromethane. The yield is generally around 70-80%, and the reaction is selective for the bromination of the available sites.

2-Bromo-4,6-diphenylnicotinonitrile finds applications in pharmaceuticals, where it is used as an intermediate in the synthesis of various drugs. It is also used in the production of sensors and semiconductors due to its electronic properties. Additionally, it can be utilized in the development of polymers and as a reagent in organic chemistry.

When handling 2-Bromo-4,6-diphenylnicotinonitrile, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up with care, using appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for specific guidelines and emergency procedures.