4-[4-(2-Pyrimidinyl)-1-piperazinyl]-1-butanamine(CAS: 33386-20-8)

4-[4-(2-Pyrimidinyl)-1-piperazinyl]-1-butanamine (CAS: 33386-20-8) is a white crystalline solid with a molecular weight of approximately 318.35 g/mol. It is soluble in water and ethanol. The compound is known for its basic nature and reacts with acids to form salts. It has poor solubility in non-polar solvents. It is a potential drug candidate and is stable under normal storage conditions.

4-[4-(2-Pyrimidinyl)-1-piperazinyl]-1-butanamine (CAS: 33386-20-8) is typically synthesized through a multi-step reaction involving the coupling of 2-pyrimidinyl bromide with 4-(2-pyrimidinyl)piperazine followed by reaction with 1-butanamine. The reaction is catalyzed by a phase-transfer catalyst and proceeds with high selectivity and yield, often higher than 90%.

4-[4-(2-Pyrimidinyl)-1-piperazinyl]-1-butanamine (CAS: 33386-20-8) finds application in the pharmaceutical industry as an intermediate for drug synthesis. It is also used in the sensor industry for developing gas-sensitive materials due to its reactivity with various analytes. Additionally, it has potential uses in the development of new materials in the semiconductor industry.

When handling 4-[4-(2-Pyrimidinyl)-1-piperazinyl]-1-butanamine (CAS: 33386-20-8), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. For safety data, refer to the Material Safety Data Sheet (MSDS/SDS).