4-bromo-1,3-benzothiazole(CAS: 767-68-0)

4-bromo-1,3-benzothiazole is a white or off-white crystalline solid with a molecular weight of approximately 215.03 g/mol. It is slightly soluble in hot water and ethanol. The compound is moderately reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a dry and cool place to prevent hydrolysis.

4-bromo-1,3-benzothiazole is typically synthesized via the bromination of 1,3-benzothiazole using bromine in the presence of a Lewis acid catalyst such as aluminum bromide. The reaction is carried out in a polar aprotic solvent like dichloromethane. The yield is usually around 80%, and the product is isolated by recrystallization.

4-bromo-1,3-benzothiazole is used in various industries, particularly in pharmaceuticals and fine chemicals. It serves as a precursor for the synthesis of other benzothiazole derivatives with potential applications in antimalarial drugs and as a component in some polymer formulations. It is also used in the development of sensors and as a ligand in coordination chemistry.

When handling 4-bromo-1,3-benzothiazole (CAS: 767-68-0), it is essential to use appropriate personal protective equipment (PPE) such as safety goggles, gloves, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation exposure. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.