5,6-Difluoro-1H-indole-2,3-dione(CAS: 774-47-0)

5,6-Difluoro-1H-indole-2,3-dione is a crystalline solid with a molecular weight of approximately 197.04 g/mol. It has low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound exhibits moderate reactivity, particularly in nucleophilic substitution reactions, making it useful in various organic synthesis processes.

5,6-Difluoro-1H-indole-2,3-dione is commonly synthesized via reactions involving the fluoroalkylation of indole followed by the formation of the dione structure. Common methods include the use of fluoroalkyl halides in the presence of a base, often using potassium carbonate or sodium hydride as catalysts.

5,6-Difluoro-1H-indole-2,3-dione finds applications in the pharmaceutical industry, where it serves as a precursor in the synthesis of bioactive compounds. It is also utilized in the development of sensors and in the semiconductor industry for its unique electronic properties.

Proper handling of 5,6-Difluoro-1H-indole-2,3-dione requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a well-ventilated area and handled in a fume hood to minimize exposure. In case of spills, immediately clean up with appropriate absorbent materials and consult the Safety Data Sheet (SDS) for further guidance.