2-(2,4-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(CAS: 68716-50-7)

2-(2,4-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a white crystalline solid with a molecular weight of approximately 323.02 g/mol. It has low water solubility but is soluble in organic solvents like dichloromethane and acetone. The compound exhibits moderate reactivity in boron-containing reactions and is stable under normal laboratory conditions.

2-(2,4-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is synthesized via a multistep route involving the bromination of 2,4-dichloroacetophenone, followed by reduction to the alcohol, and subsequent reaction with methyl vinyl ketone and sodium hydride. The final step is the dioxaborolane formation using boron tribromide and a palladium catalyst.

2-(2,4-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is utilized in the pharmaceutical and chemical industries for its reactivity in boron-containing reactions, particularly in the synthesis of bioactive molecules and as a key intermediate in polymer and sensor applications.

When handling 2-(2,4-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Handle in a well-ventilated area or fume hood to avoid inhalation. In case of spill, immediately clean up using appropriate absorbent materials and follow local safety guidelines. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.