(3S)-Tetrahydro-2H-pyran-3-ol(CAS: 72886-97-6)

(3S)-Tetrahydro-2H-pyran-3-ol is a colorless to white crystalline solid with a molecular weight of approximately 112.11 g/mol. It has a faint, sweet odor and is soluble in water, ethanol, and ether. It is mildly acidic and can undergo reactions such as esterification and reduction. This compound is often used as a precursor in organic synthesis due to its reactive nature.

(3S)-Tetrahydro-2H-pyran-3-ol can be synthesized by the reduction of (3S)-tetrahydro-2H-pyranone using lithium aluminum hydride (LAH) as a catalyst. This process provides good yields and selectivity. Other methods include the hydrogenation of 1,3-dioxane-2,5-dione followed by reduction using sodium borohydride.

(3S)-Tetrahydro-2H-pyran-3-ol is widely used in the pharmaceutical, polymer, and chemical industries. It is a key intermediate in the synthesis of various drugs and medicinals. Additionally, it serves as a building block in the production of polymers and is utilized in the development of sensors and semiconductors.

When handling (3S)-Tetrahydro-2H-pyran-3-ol, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents and proper disposal methods. Refer to the Safety Data Sheet (SDS) for detailed guidelines on handling and storage.