(2E)-4-Ethoxy-4-oxo-2-butenoic acid(CAS: 2459-05-4)

(2E)-4-Ethoxy-4-oxo-2-butenoic acid is a white crystalline solid with a molecular weight of approximately 146.17 g/mol. It is slightly soluble in water and soluble in organic solvents like ethanol and acetone. The compound is known for its low reactivity under normal conditions but can undergo hydrolysis in the presence of water. It has a pKa of about 2.5, making it acidic. This compound is used in various applications due to its chemical stability and reactivity.

The synthesis of (2E)-4-Ethoxy-4-oxo-2-butenoic acid typically involves the reaction of ethyl acetoacetate with ethanol in the presence of a catalytic amount of a strong acid like sulfuric acid. The product is then purified by recrystallization from water. This method provides good yields and high purity. The reaction is exothermic, and care must be taken to control the temperature to prevent side reactions.

(2E)-4-Ethoxy-4-oxo-2-butenoic acid is used in pharmaceuticals, where it serves as a precursor in the synthesis of certain drug molecules. It is also utilized in the production of surfactants, sensors, and as a building block in the synthesis of monomers for polymers. Additionally, this compound finds application in the preparation of functional materials in the semiconductor industry.

When handling (2E)-4-Ethoxy-4-oxo-2-butenoic acid (CAS: 2459-05-4), ensure the use of appropriate personal protective equipment (PPE), including gloves and safety goggles. It should be stored in a dry, cool place away from moisture and heat sources. Spills should be cleaned up carefully using absorbent materials, and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures. This compound is not flammable, but it should be handled with care due to its acidic nature and potential to undergo hydrolysis in the presence of water.