Aripiprazole Impurity 31 (2,6-quinolinediol)(CAS: 19315-93-6)

Aripiprazole Impurity 31, also known as 2,6-quinolinediol, is a crystalline compound with a molecular weight of approximately 142.18 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and methanol. Chemically, it is a relatively stable compound under normal conditions but can react with strong acids or bases. It is important to handle it under controlled conditions to avoid degradation.

Aripiprazole Impurity 31 is synthesized through the reduction of 1,2-dihydro-2,6-dimethyl-3-(1,3-dioxoisoindolin-2-yl) quinoline with a hydrogenation catalyst such as palladium on carbon. The reaction typically requires high purity starting materials and is conducted in an inert atmosphere to prevent oxidation. The yield is usually around 85-90%, and the process is optimized for selectivity and purity.

Aripiprazole Impurity 31 is primarily used in the pharmaceutical industry as a by-product or impurity in the synthesis of the active pharmaceutical ingredient Aripiprazole. It is also of interest in research for its pharmacological properties and potential in drug discovery. Limited applications in other industries such as polymers or sensors are found but are not as prominent.

When handling Aripiprazole Impurity 31, it is crucial to use appropriate personal protective equipment (PPE) such as gloves, safety glasses, and lab coats. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and disposal information.