1-(2-Chloro-3-pyridinyl)ethanone(CAS: 55676-21-6)

1-(2-Chloro-3-pyridinyl)ethanone is a crystalline solid with a molecular weight of approximately 182.69 g/mol. It has a solubility of about 0.32 g/100 mL in water. Chemically, it is mildly reactive, particularly in the presence of moisture and air. It is stable at room temperature and under normal atmospheric conditions, but care should be taken to store it in a dry and cool place to prevent hydrolysis.

1-(2-Chloro-3-pyridinyl)ethanone can be synthesized by a condensation reaction between 2-chloro-3-pyridinone and ethyl bromide in the presence of a base like sodium bicarbonate. The yield is around 70-80%, and the reaction is typically carried out in a solvent like methanol or ethanol. The product is isolated by filtration and recrystallization.

1-(2-Chloro-3-pyridinyl)ethanone is used in several industries. In pharmaceuticals, it serves as a precursor for the synthesis of various drugs. It finds applications in the production of polymers as a monomer or intermediate. It is also utilized in the development of sensors and in the semiconductor industry for specific chemical treatments.

When handling 1-(2-Chloro-3-pyridinyl)ethanone, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be used in a well-ventilated area or in a fume hood to minimize inhalation risks. Spills should be cleaned up carefully, using appropriate absorbent materials. In case of skin contact, wash the affected area with soap and water. For detailed safety information, refer to the Safety Data Sheet (SDS).