Methyl 2-(1-methylpiperidin-4-yl)acetate(CAS: 95533-25-8)

Methyl 2-(1-methylpiperidin-4-yl)acetate is a colorless to pale yellow liquid with a molecular weight of approximately 204.3 g/mol. It has a p*Ka of about 12.2, indicating a basic nature. The compound is slightly soluble in water but miscible with many organic solvents. It exhibits moderate reactivity in the presence of strong acids and bases, and is stable under normal conditions but may degrade at high temperatures. It is commonly used in organic synthesis due to its reactivity and stability.

Methyl 2-(1-methylpiperidin-4-yl)acetate is typically synthesized via an esterification reaction between 2-(1-methylpiperidin-4-yl)acetic acid and methanol. The reaction is catalyzed by a solid acid such as Amberlicat IR 120, and proceeds under mild conditions. The yield is usually around 80-90%, with good selectivity and purity.

Methyl 2-(1-methylpiperidin-4-yl)acetate is primarily used in the pharmaceutical industry as a precursor for organic synthesis. It is also utilized in the polymer industry as a modifier. Additionally, it finds applications in the production of sensors and semiconductors due to its reactivity and chemical properties.

When handling Methyl 2-(1-methylpiperidin-4-yl)acetate, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific handling and storage instructions. This compound is stable under normal conditions but should be stored in a cool, dry place away from strong acids and bases.