Ethyl 4-methoxy-3-oxobutanoate(CAS: 66762-68-3)

Ethyl 4-methoxy-3-oxobutanoate is a colorless liquid with a molecular weight of approximately 158.19 g/mol. It has a slight fruity odor and a density of about 0.94 g/cm³. It is slightly soluble in water but miscible with most organic solvents. The compound is moderately reactive and can undergo ester hydrolysis and nucleophilic substitution reactions.

Ethyl 4-methoxy-3-oxobutanoate is usually synthesized via a condensation reaction of 4-methoxy-3-oxobutanoic acid with ethanol in the presence of a catalytic amount of acid. The reaction is typically carried out under mild conditions, and the product can be isolated by crystallization or distillation, with good yield and selectivity.

Ethyl 4-methoxy-3-oxobutanoate is used in the pharmaceutical industry for the synthesis of certain medications, particularly those requiring specific functional groups. It also finds applications in the polymer industry for modifying the properties of polymer materials. Additionally, it is used in the sensor industry as a component in chemical sensors, and in the semiconductor industry as a precursor in the fabrication of electronic devices.

When handling Ethyl 4-methoxy-3-oxobutanoate, proper personal protective equipment (PPE) should be worn, including gloves, safety goggles, and a lab coat. Work should be carried out in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials and the area should be flushed with water. Safety data sheets (SDS) should be consulted for detailed emergency response procedures and storage recommendations.