7-Chloro-1H-indole(CAS: 53924-05-3)

7-Chloro-1H-indole is a crystalline solid with a molecular weight of approximately 165.01 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and dichloromethane. The compound is moderately reactive, particularly in the presence of nucleophiles, and can undergo substitution reactions. It is stable under normal storage conditions but should be protected from moisture and light.

7-Chloro-1H-indole is commonly synthesized via the indole derivative transformation method, where indole is chlorinated at the 7-position using thionyl chloride in the presence of a Lewis acid catalyst. Other methods include chlorination of 1H-indole using fuming sulfuric acid under controlled conditions. The synthesis typically yields 70-85% purity with good selectivity.

7-Chloro-1H-indole is used in various industries, primarily in the pharmaceutical sector for the synthesis of medicinal compounds. It is also applied in the production of certain agrochemicals and as a precursor in the development of sensors and materials for electronic devices.

When handling 7-Chloro-1H-indole, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a fume hood to minimize exposure. Spills should be contained and disposed of according to local regulations. Safety data sheets (SDS) should be consulted for detailed handling and storage instructions.