(6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine(CAS: 187235-37-6)

(6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine is a crystalline solid with a molecular weight of approximately 438.37 g/mol. It has a low solubility in water but is soluble in organic solvents such as dichloromethane and acetonitrile. The compound is characterized by its high reactivity towards nucleophiles and electrophiles, particularly due to the nitro and trifluoromethoxy groups.

(6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine can be synthesized via a multi-step process involving the protection of the imidazole ring, introduction of the nitro and trifluoromethoxy groups, followed by deprotection and ring closure. Commonly used catalysts include acid catalysts such as trifluoroacetic acid, and the process typically yields the desired product with good selectivity.

(6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine is primarily used in the pharmaceutical industry for the development of new drug candidates, particularly in the areas of anti-inflammatory and antiviral treatments. It also finds applications in the production of sensors and semiconductors, where its unique chemical structure can contribute to enhanced performance.

When handling (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be handled with appropriate absorbent materials, and the area should be well-ventilated. Safety data sheets (SDS) should be consulted for detailed information on handling and disposal.