1-Isobutyryl-2-pyrrolidinone(CAS: 92475-82-6)

1-Isobutyryl-2-pyrrolidone is a colorless liquid with a molecular weight of 167.23 g/mol. It has a slight pyrrolidone odor. The compound is soluble in water and organic solvents. Chemically, it is stable but reacts with strong acids and bases. It is a good solvent and used in various applications due to its unique properties.

1-Isobutyryl-2-pyrrolidone is synthesized through the amide formation reaction between isobutyryl chloride and pyrrolidone. The reaction is conducted in the presence of a base like sodium hydroxide in an aprotic solvent. The yield is typically around 70-80%, and the product is isolated through crystallization or by distillation.

1-Isobutyryl-2-pyrrolidone is widely used in the pharmaceutical industry as a precursor for drug synthesis. It is also utilized in the polymer industry for modifying the properties of polymers. Additionally, it is used in the production of sensors and semiconductors for its solvent and reactivity properties.

When handling 1-Isobutyryl-2-pyrrolidone, use proper personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Store the compound in a cool, well-ventilated area away from strong acids and bases. In case of a spill, use appropriate spill cleanup procedures and refer to the Safety Data Sheet (SDS) for detailed instructions. Work in a fume hood to minimize exposure to vapors.