4-Chlorothieno[2,3-d]pyrimidine(CAS: 14080-59-2)

4-Chlorothieno[2,3-d]pyrimidine is a crystalline compound with a molecular weight of approximately 211.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and acetonitrile. Chemically, it exhibits good stability but can undergo ring-opening reactions under certain conditions. Its reactivity towards nucleophiles is notable, making it useful in various synthetic transformations.

4-Chlorothieno[2,3-d]pyrimidine can be synthesized via a nucleophilic substitution reaction where a chloroalkylthiophene undergoes a substitution with a pyrimidine ring. Commonly, this involves the use of thiophene and chloropyrimidine in the presence of a base like potassium carbonate. The reaction yields a product with high selectivity and a good yield under optimized conditions.

4-Chlorothieno[2,3-d]pyrimidine is primarily used in the pharmaceutical industry for its biological activity. It also finds applications in the development of sensors and semiconductors due to its electronic properties. Its use in polymers is limited but possible, particularly in tailored materials for specific electronic applications.

When handling 4-Chlorothieno[2,3-d]pyrimidine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled carefully with appropriate absorbents, and disposal should follow local regulations. Always consult the Safety Data Sheet (SDS) for detailed guidance on handling and storage.