6-(Trifluoromethyl)-4(1H)-pyrimidinone(CAS: 1546-78-7)

6-(Trifluoromethyl)-4(1H)-pyrimidinone (CAS: 1546-78-7) is a white crystalline solid with a molecular weight of approximately 191.07 g/mol. It has a melting point of 135-137°C and is slightly soluble in water. This compound exhibits good stability under normal conditions but can be reactive under certain conditions, particularly in the presence of strong acids or bases. It is used in various applications due to its unique chemical properties.

6-(Trifluoromethyl)-4(1H)-pyrimidinone (CAS: 1546-78-7) can be synthesized via several routes, commonly involving the reaction of 4-chloropyrimidin-2-one with trifluoroacetyl chloride. The process typically requires the use of a catalyst and proceeds with good selectivity and yield. Detailed synthesis methods and conditions are available in the literature.

6-(Trifluoromethyl)-4(1H)-pyrimidinone (CAS: 1546-78-7) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also applied in the polymer industry for modifying polymer properties and in the semiconductor industry for its use in manufacturing processes. Additionally, it has potential applications in sensors and other advanced materials.

When handling 6-(Trifluoromethyl)-4(1H)-pyrimidinone (CAS: 1546-78-7), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and protective clothing. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate methods, and the substance should be stored in a cool, dry place away from heat sources. Always refer to the Safety Data Sheet (SDS) for specific handling guidelines and emergency procedures.