4-Fluoro-2-methylaniline(CAS: 452-71-1)

4-Fluoro-2-methylaniline (CAS: 452-71-1) is a white crystalline solid with a molecular weight of 141.03 g/mol. It has a solubility of about 6 g/L in water and is slightly soluble in ethanol. This compound reacts readily with bases and is moderately reactive. It is used in various chemical syntheses and as a starting material in the pharmaceutical industry.

4-Fluoro-2-methylaniline (CAS: 452-71-1) is typically synthesized by the reaction of 2-methylaniline with hydrogen fluoride. This process involves the nucleophilic substitution of the amino group by a fluoride ion. The reaction is carried out at low temperatures, and the product is isolated by recrystallization. This method provides a yield of up to 85%.

4-Fluoro-2-methylaniline (CAS: 452-71-1) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It is also utilized in the production of dyes and as a reagent in analytical chemistry for the detection of certain compounds. Its properties make it suitable for applications in polymer chemistry and semiconductor manufacturing.

When handling 4-Fluoro-2-methylaniline (CAS: 452-71-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound is corrosive and can cause skin irritation. Work should be performed in a fume hood to minimize exposure. In case of spill, avoid direct contact and use appropriate spill cleanup procedures as outlined in the safety data sheet (SDS).