2,6-Diamino-4-(pyrrolidin-1-yl)pyrimidine 1-oxide(CAS: 55921-65-8)

2,6-Diamino-4-(pyrrolidin-1-yl)pyrimidine 1-oxide (CAS: 55921-65-8) is a crystalline solid with a molecular weight of approximately 285.34 g/mol. It has a moderate solubility in water and is poorly soluble in common organic solvents. The compound is moderately reactive towards acid, and it exhibits good thermal stability up to 150°C. It is insoluble in most common organic solvents and has a pKa of about 8.5.

2,6-Diamino-4-(pyrrolidin-1-yl)pyrimidine 1-oxide is typically synthesized from 2,6-diaminopyrimidine and pyrrolidine using a condensation reaction. The process involves the use of a suitable base like sodium hydride or lithium diisopropylamide (LDA) as a catalyst. The reaction is carried out in an aprotic solvent such as dimethylformamide (DMF) or N,N-dimethylacetamide (DMAc). The yield is generally around 70-80%, and the product can be purified by recrystallization from water or ethanol.

2,6-Diamino-4-(pyrrolidin-1-yl)pyrimidine 1-oxide (CAS: 55921-65-8) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It also finds applications in the polymer industry for the development of new materials. Additionally, due to its functional groups, it can be used in semiconductors and sensors for its catalytic and electronic properties.

When handling 2,6-Diamino-4-(pyrrolidin-1-yl)pyrimidine 1-oxide (CAS: 55921-65-8), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a fume hood to minimize exposure to air. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be well-ventilated. Safety data sheets (SDS) should always be consulted for detailed handling and disposal information. Storage should be in a dry, cool place, away from heat sources and oxidizing agents.