4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide(CAS: 127-79-7)

4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide is a white to off-white crystalline powder with a molecular weight of approximately 304.34 g/mol. It is slightly soluble in water and organic solvents. The compound is reactive towards nucleophiles and is known for its stability in acidic and basic conditions. It forms a stable crystalline form at room temperature.

4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide can be synthesized via the condensation of 4-methyl-2-pyrimidinamine with benzenesulfonyl chloride. The reaction is catalyzed by a strong acid, typically trifluoroacetic acid, in dichloromethane. The yield is typically 80-85%, and the product is obtained as a white solid.

4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also finds applications in the chemical industry for its reactivity and stability in various chemical processes.

When handling 4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be used in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.