(1S)-1-[4-(acetyloxy)phenyl]prop-2-en-1-yl acetate(CAS: 52946-22-2)

(1S)-1-[4-(acetyloxy)phenyl]prop-2-en-1-yl acetate (CAS: 52946-22-2) is a colorless to white crystalline solid with a molecular weight of approximately 252.33 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound is relatively stable under normal conditions but can undergo hydrolysis in the presence of water. It is used as a starting material in organic synthesis and has a pKa of around 14.

(1S)-1-[4-(acetyloxy)phenyl]prop-2-en-1-yl acetate (CAS: 52946-22-2) is synthesized by reacting 2-acetoxybenzaldehyde with propargyl acetate in the presence of a catalytic amount of a Lewis acid like aluminum trichloride. The reaction is typically carried out in an inert solvent such as dichloromethane. The yield is generally between 70-80%, and the stereochemistry at the chiral center is maintained through selective addition. The product is purified by recrystallization from a suitable solvent.

(1S)-1-[4-(acetyloxy)phenyl]prop-2-en-1-yl acetate (CAS: 52946-22-2) is used in the pharmaceutical industry as a precursor for the synthesis of various bioactive molecules. It is also employed in the production of polymer additives and as a fragrance intermediate in the chemical industry. Additionally, it can be utilized in the development of sensors and semiconductors due to its functional groups and structural features.

When handling (1S)-1-[4-(acetyloxy)phenyl]prop-2-en-1-yl acetate (CAS: 52946-22-2), it is important to wear appropriate personal protective equipment (PPE), including gloves and eye protection. Work should be conducted in a well-ventilated fume hood due to its potential volatility. Spills should be handled carefully and cleaned with appropriate solvents. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.