7-Ketodeoxycholic acid(CAS: 911-40-0)

7-Ketodeoxycholic acid is a crystalline compound with a molecular weight of approximately 376.35 g/mol. It has a low solubility in water but is soluble in many organic solvents such as ethanol and chloroform. Chemically, it is relatively stable but can react with strong bases to form salts. It is also susceptible to hydrolysis under basic conditions.

7-Ketodeoxycholic acid is typically synthesized via the oxidation of deoxycholic acid. The process involves the use of peroxyacetic acid or hydrogen peroxide as the oxidizing agent. The reaction is conducted in the presence of a catalyst, such as a transition metal complex, to ensure high selectivity and yield, often around 80-90%.

7-Ketodeoxycholic acid is primarily used in the pharmaceutical industry for its role as a bile acid and as a precursor in the synthesis of other compounds. It is also used in research applications, particularly in the development of sensors and semiconductors due to its unique chemical properties.

When handling 7-Ketodeoxycholic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. Ensure that the work is conducted in a well-ventilated area or in a fume hood. Spills should be cleaned up using absorbent materials and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.