2-(1H-Pyrrol-1-yl)ethanamine(CAS: 29709-35-1)

2-(1H-Pyrrol-1-yl)ethanamine is a colorless liquid with a molecular weight of approximately 113.14 g/mol. It has a high solubility in water and ethanol. Chemically, it is relatively stable but reactive towards strong oxidizing agents. It has a pKa of about 11.2, indicating basic properties. The compound is slightly soluble in nonpolar solvents like hexane and toluene.

2-(1H-Pyrrol-1-yl)ethanamine can be synthesized via a multi-step process starting from pyrrole and ethylamine. Common methods involve the condensation of pyrrole with an amine to form an imine followed by reduction with a reducing agent like sodium borohydride to produce the amine. The overall reaction is selective and yields up to 90% of the desired product. Detailed synthesis protocols and conditions are available in the literature.

2-(1H-Pyrrol-1-yl)ethanamine is primarily used in the pharmaceutical industry for the synthesis of certain drugs and intermediates. It also finds applications in the polymer industry for the modification of polymers and in the production of advanced materials. Additionally, it is used in the sensor industry for the development of gas sensors and in the semiconductor industry for chemical vapor deposition processes.

When handling 2-(1H-Pyrrol-1-yl)ethanamine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to prevent inhalation and skin contact. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed information and emergency procedures.