2-Methoxy-5-nitroaniline hydrochloride (1:1)(CAS: 67827-72-9)

2-Methoxy-5-nitroaniline hydrochloride (CAS: 67827-72-9) is a crystalline solid with a molecular weight of approximately 217.04 g/mol. It has a pKa of 1.5 and is highly soluble in water, with a solubility of 12.8 g/100 mL at 20°C. The compound is moderately reactive, especially towards reducing agents and bases. It exhibits good solubility in common organic solvents like methanol and ethanol.

2-Methoxy-5-nitroaniline hydrochloride is typically synthesized by the reaction of 2-methoxy-5-nitroaniline with hydrochloric acid. The process involves dissolving the aniline in hydrochloric acid, followed by recrystallization from an appropriate solvent to obtain the hydrochloride salt. The reaction is carried out under mild conditions, and the yield is generally around 85-90%.

2-Methoxy-5-nitroaniline hydrochloride (CAS: 67827-72-9) is primarily used in pharmaceuticals and dyes. It serves as a precursor for the synthesis of various pharmaceutical compounds and also as a coloring agent in textile dyes. Additionally, it finds applications in the production of some organic pigments and as a reagent in analytical chemistry.

When handling 2-Methoxy-5-nitroaniline hydrochloride (CAS: 67827-72-9), it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be carried out in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed emergency procedures and safe handling instructions.