N-Methyl pemetrexed(CAS: 869791-42-4)

N-Methyl pemetrexed (CAS: 869791-42-4) is an antifolate drug. It exists in a crystalline form with a molecular weight of approximately 326.4 g/mol. This compound is sparingly soluble in water and ethanol. It is chemically stable but can undergo hydrolysis under basic conditions. N-Methyl pemetrexed should be stored at room temperature away from moisture and light.

N-Methyl pemetrexed is synthesized via a multi-step process involving the protection of the pemetrexed core, methylation, and subsequent deprotection. Commonly used catalysts and reagents include sulfuric acid, methyl iodide, and sodium methoxide. This method yields a product with high purity and selectivity, making it suitable for pharmaceutical applications.

N-Methyl pemetrexed (CAS: 869791-42-4) is primarily used in the pharmaceutical industry for treating certain types of cancer. It is also of interest in academic and industrial research for its antifolate properties. Some applications include drug discovery and development, as well as its use in medical treatments.

When handling N-Methyl pemetrexed (CAS: 869791-42-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to minimize inhalation risks. Store the compound in a cool, dry place, away from incompatible materials like strong acids. In the event of a spill, consult the Safety Data Sheet (SDS) for proper cleanup procedures.