2-Methyl-2-propanyl [(2S)-2-oxiranylmethyl]carbamate(CAS: 161513-47-9)

2-Methyl-2-propanyl [(2S)-2-oxiranylmethyl]carbamate is a colorless or slightly yellow liquid with a molecular weight of approximately 137.2 g/mol. It has low solubility in water but is soluble in organic solvents such as ethanol and acetone. The compound exhibits typical reactivity of epoxides and carbamates. It is stable under normal conditions but can react with strong nucleophiles and bases.

2-Methyl-2-propanyl [(2S)-2-oxiranylmethyl]carbamate can be synthesized via a multistep reaction involving the formation of an oxirane ring followed by a nucleophilic substitution. Commonly, it is prepared by reacting 2-methyl-2-propanol with phosgene in the presence of a base such as pyridine. The reaction yields the desired compound with good selectivity and moderate to high yields.

2-Methyl-2-propanyl [(2S)-2-oxiranylmethyl]carbamate is primarily used in the pharmaceutical industry for the synthesis of various drug molecules. It is also employed in the polymer industry for modifying the properties of polymers and in the development of sensing technologies, particularly in the detection of specific analytes.

When handling 2-Methyl-2-propanyl [(2S)-2-oxiranylmethyl]carbamate, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a fume hood to minimize exposure. Spills should be immediately cleaned up with appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for proper disposal instructions. Handling should be done with care due to its reactivity with strong bases and nucleophiles.