Ag(i)-catalyzed three-component radical cascade synthesis of 3-organoselenyl chromones from 2-methoxyaryl alkynones, Se powder and organic boronic acids
Literature Information
Nan Sun, Zengguo Qiao, Xiaolong Liu, Zhi Qiao, Liqun Jin, Xinquan Hu
Herein, we present a new Ag(I)-catalyzed three-component radical cascade reaction for the construction of 3-organoselenyl chromones from 2-methoxyaryl alkynones, Se powder and organic boronic acids. With 20 mol% of AgNO3 as a catalyst, 10 mol% of SDS as an additive and under an O2 atmosphere in 1,4-dioxane, a wide range of multi-functionalized 3-organoselenyl chromones have been achieved in good to excellent yields. This protocol features easy availability of starting materials, simple operation, high step-economy and high structural diversity of products.
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