(3beta,7beta,12beta)-3,7,12-Trihydroxy-11,15,23-trioxolanost-8-en-26-oic acid
CAS Number:
98665-22-6
Molecular Formula:
C30H44O8
Bacterial outer membrane vesicle-modified metal–organic frameworks for sonodynamic therapy–immunotherapy of breast cancer
Literature Information
Publication Date
2023-11-23
DOI
10.1039/D3NJ03511E
Impact Factor
3.591
Authors
Ziwen Zhang, Jiawei Tu, Xiufeng Kuang, Mengya Shi, Yumeng Zhang, He Li, Jiesheng Huang, Li Wang, Huafang Yuan
View Original
Abstract
Triple negative breast cancer seriously threatens the life health of women. Here, we develop a metal–organic framework based a nanoplatform for sonodynamic therapy–immunotherapy of breast cancer, loaded with the sonosensitizer chlorin e6 and modified bacterial outer membrane vesicles (OMVs). Sonodynamic therapy not only produced reactive oxygen species to kill tumor cells directly, but also promoted anti-tumor immunity. More importantly, OMV modification improved tumor targeting and immune activation of the nanoplatform, and further increased dendritic cell maturation and T cell infiltration in the tumor microenvironment. This novel therapeutic strategy led to a notable inhibitory effect on the development of breast cancer in mice.
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Source Journal
New Journal of Chemistry
CiteScore:
5.3
Self-citation Rate:
3.7%
Articles per Year:
2153
NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.
Recommended Compounds
![1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione structure](https://static.chemtradehub.com/structs/57-/57-96-5-efcc.webp "1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione structure")
1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione
CAS Number:
57-96-5
Molecular Formula:
C23H20N2O3S
1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS Number:
1020174-04-2
Molecular Formula:
C10H17BN2O2
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