Bacterial outer membrane vesicle-modified metal–organic frameworks for sonodynamic therapy–immunotherapy of breast cancer

Literature Information

Publication Date 2023-11-23
DOI 10.1039/D3NJ03511E
Impact Factor 3.591
Authors

Ziwen Zhang, Jiawei Tu, Xiufeng Kuang, Mengya Shi, Yumeng Zhang, He Li, Jiesheng Huang, Li Wang, Huafang Yuan


View Original

Abstract

Triple negative breast cancer seriously threatens the life health of women. Here, we develop a metal–organic framework based a nanoplatform for sonodynamic therapy–immunotherapy of breast cancer, loaded with the sonosensitizer chlorin e6 and modified bacterial outer membrane vesicles (OMVs). Sonodynamic therapy not only produced reactive oxygen species to kill tumor cells directly, but also promoted anti-tumor immunity. More importantly, OMV modification improved tumor targeting and immune activation of the nanoplatform, and further increased dendritic cell maturation and T cell infiltration in the tumor microenvironment. This novel therapeutic strategy led to a notable inhibitory effect on the development of breast cancer in mice.

Related Literature

A ratiometric solvent polarity sensing Schiff base molecule for estimating the interfacial polarity of versatile amphiphilic self-assemblies

Rini Majumder, Yeasmin Sarkar, Suresh K. Jewrajka, Ambarish Ray, Partha Pratim Parui

2016-05-04 Communication

DOI: 10.1039/C6AN00582A

A rhodol-hemicyanine based ratiometric fluorescent probe for real-time monitoring of glutathione dynamics in living cells

Minghao Ren, Linfang Wang, Xin Lv, Yuanqiang Sun, Hu Chen, Keyuan Zhang, Qi Wu, Yurong Bai, Wei Guo

2019-11-01 Paper

DOI: 10.1039/C9AN01852B

Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis

Jonathan Sjögren, Fredrik Olsson, Alain Beck

2016-05-04 Minireview

DOI: 10.1039/C6AN00071A

A single-bead telomere sensor based on fluorescence resonance energy transfer

Xiao Fan, Qiaoli Yue, Yanyan Li, Yingya Liu, Lu-Lu Qu, Yingnan Cao

2016-03-14 Paper

DOI: 10.1039/C5AN02543E

An in vivo quantitative Raman-pH sensor of arterial blood based on laser trapping of erythrocytes

Manman Lin, Bin Xu, Huilu Yao, Aiguo Shen, Jiming Hu

2016-03-23 Paper

DOI: 10.1039/C5AN02315G

Fluorescence array-based sensing of nitroaromatics using conjugated polyelectrolytes

Yu Zong Chen

2016-05-03 Communication

DOI: 10.1039/C6AN00678G

Paper-based biodetection using luminescent nanoparticles

M. Omair Noor, Ulrich J. Krull

2016-04-13 Critical Review

DOI: 10.1039/C6AN00129G

Surface-enhanced Raman spectroscopy (SERS) characterisation of abasic sites in DNA duplexes

Luca Guerrini

2019-11-05 Communication

DOI: 10.1039/C9AN02040C

You might also like

Compound Q&A

What precautions should be taken when handling 4-(2-Furylmethyl)thiomorpholine 1,1-dioxide (CAS: 79206-94-3)?

When handling 4-(2-Furylmethyl)thiomorpholine 1,1-dioxide (CAS: 79206-94-3), it ...

79206-94-34-(2-Furylmethyl)thi...
Compound Q&A

What precautions should be taken when handling 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide (CAS: 71320-77-9)?

When handling 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide (CAS: 71320-77-9), it...

71320-77-94-Chloro-N-[2-(4-mor...
Compound Q&A

How should waste containing 2-[2-(2-Methoxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate (CAS: 62921-74-8) be handled?

Waste containing this compound (CAS: 62921-74-8) should be handled according to ...

62921-74-82-[2-(2-Methoxyethox...
Compound Q&A

How should waste containing (S)-Methyl 2-amino-3-cyclohexylpropanoate be handled?

Waste containing (S)-Methyl 2-amino-3-cyclohexylpropanoate should be collected i...

40056-18-6(S)-Methyl 2-amino-3...
166882-70-85-({4-[(2S,4R)-4-Hyd...
Compound Q&A

Are there alternatives to (2E)-3-(3,4-Dichlorophenyl)acrylic acid (CAS: 7312-27-8) in synthesis?

There are several alternatives to (2E)-3-(3,4-Dichlorophenyl)acrylic acid in syn...

7312-27-8(2E)-3-(3,4-Dichloro...
Compound Q&A

How should Ethyl 6-(2-nitrophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylate (CAS: 925437-84-9) be stored?

Ethyl 6-(2-nitrophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylate (CAS: 925437-84...

925437-84-9Ethyl 6-(2-nitrophen...
Compound Q&A

How should waste containing 2-(1,3-Thiazol-2-yl)ethanamine (CAS: 18453-07-1) be handled?

Waste containing 2-(1,3-Thiazol-2-yl)ethanamine (CAS: 18453-07-1) should be coll...

18453-07-12-(1,3-Thiazol-2-yl)...
Compound Q&A

How is Methyl 5-iodo-2-methylbenzoate (CAS: 103440-54-6) typically synthesized?

Methyl 5-iodo-2-methylbenzoate can be synthesized through the iodination of meth...

103440-54-6Methyl 5-iodo-2-meth...
Compound Q&A

How is 5-Chloro[1,2,4]triazolo[1,5-a]pyridine (CAS: 1427399-34-5) typically synthesized?

5-Chloro[1,2,4]triazolo[1,5-a]pyridine is commonly synthesized via the condensat...

1427399-34-55-Chloro[1,2,4]triaz...

Source Journal

New Journal of Chemistry

New Journal of Chemistry
CiteScore: 5.3
Self-citation Rate: 3.7%
Articles per Year: 2153

NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.