Inducing and monitoring mitochondrial pH changes with an iridium(iii) complex via two-photon lifetime imaging
Literature Information
Publication Date
2023-10-05
DOI
10.1039/D3DT02541A
Impact Factor
4.39
Authors
Meng Hu, Xin-Lan Zhou, Tian-Xin Xiao, Liang Hao, Yi Li
View Original
Abstract
Real-time monitoring of mitochondrial dynamic changes plays a key role in the development of mitochondria-targeted anticancer theranostic agents. In this work, a pH-responsive and mitochondria-targeted cyclometalated iridium(III) complex MitoIr-NH has been explored as a novel anticancer agent. MitoIr-NH displayed pH-responsive phosphorescence intensity and lifetime, accumulated in mitochondria, showed higher antiproliferative activity and induced a series of mitochondria-related events. Moreover, MitoIr-NH could simultaneously induce mitophagy and quantitatively monitor mitochondrial pH changes through two-photon phosphorescence lifetime imaging microscopy (TPPLIM) in a real-time manner.
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Source Journal
Dalton Transactions
CiteScore:
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Self-citation Rate:
11.4%
Articles per Year:
1868
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