Dopamine oxidation promoted by human telomeric DNA models in the presence of a Cu(ii) terpyridine chelate

Literature Information

Publication Date 2023-11-30
DOI 10.1039/D3CC05530B
Impact Factor 6.222
Authors

Guoqing Jia, Can Li


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Abstract

We found that under oxidative stress conditions, the coexistence of human telomeric DNA (HT-DNA) and a copper-terpyridine metallodrug can accelerate dopamine oxidation. The unwinding of HT-DNA from a duplex to cytosine-rich (C-rich) and guanine-rich (G-rich) single strands promotes dopamine oxidation in a general order of C-rich > G-rich > duplex. Along with dopamine oxidation, HT-DNA also undergoes severe damage.

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