Non-metal-mediated N-oxyl radical (TEMPO)-induced acceptorless dehydrogenation of N-heterocycles via electrocatalysis
Literature Information
Huiqing Hou, Xinhua Ma, Yaling Ye, Mei Wu, Sunjie Shi, Wenhe Zheng, Mei Lin, Weiming Sun, Fang Ke
The development of protocols for direct catalytic acceptorless dehydrogenation of N-heterocycles with metal-free catalysts holds the key to difficulties in green and sustainable chemistry. Herein, an N-oxyl radical (TEMPO) acting as an oxidant in combination with electrochemistry is used as a synthesis system under neutral conditions to produce N-heterocycles such as benzimidazole and quinazolinone. The key feature of this protocol is the utilization of the TEMPO system as an inexpensive and easy to handle radical surrogate that can effectively promote the dehydrogenation reaction. Mechanistic studies also suggest that oxidative TEMPOs redox catalytic cycle participates in the dehydrogenation of 2,3-dihydro heteroarenes.
Related Literature
Commonwealth of Massachusetts. Report of Division of Food and Drugs for the first quarter, 1941
DOI: 10.1039/AN942670102A
Spectrophotometric terms and symbols. Report of a panel appointed by the Publication Committee
DOI: 10.1039/AN942670227A
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