Water-promoted regio-selective trifluoromethylation of vinyl conjugated diazoacetates
Literature Information
Publication Date
2021-12-01
DOI
10.1039/D1QO01654G
Impact Factor
5.281
Authors
Xinxin Han, Xin Liu, Yueyun Bao, Hunahuan Song, Yu-Rou Zhao, Xiaoying Wang, Junjie Zhang, Le Liu, Xin-Hua Duan, Jinbo Hu, Mingyou Hu
View Original
Abstract
An efficient trifluoromethylation reaction of vinyldiazoacetates under mild reaction conditions was depicted. Pre-generated CuCF3 was used as a trifluoromethylation reagent and water acted as both a promoter and proton source. The reaction is compatible with a broad scope of functional groups and easy to scale-up. The wide functional group tolerance of the reaction enables further synthetic manipulation of the products.
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Organic Chemistry Frontiers
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