Cobalt-catalyzed coupling reactions of 2-halobenzamides with alkynes: investigation of ligand-controlled dual pathways
Literature Information
Publication Date
2021-09-24
DOI
10.1039/D1QO01402A
Impact Factor
5.281
Authors
Vijaykumar H. Thorat, Hasil Aman, Yu-Lin Tsai, Gangaram Pallikonda, Gary Jing Chuang, Jen-Chieh Hsieh
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Abstract
The Co-catalyzed reactions of 2-halobenzamides and alkynes to form isoquinolones or 2-vinyl benzamides are described here. The formation of the two selective products can be fully controlled by adopted ligands. A study of the mechanism demonstrated that these two reactions proceed through different pathways. The radical process and the two-electron transfer activation of the C–X bond are respectively proposed for these two reactions.
Related Literature
Proceedings of the Society of Public Analysts and other Analytical Chemists
Other
DOI: 10.1039/AN942670001A
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide structure](https://static.chemtradehub.com/structs/852/852212-89-6-5ef9.webp "N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide structure")
N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide
CAS Number:
852212-89-6
Molecular Formula:
C15H15F3N2O2S
![(2S)-2-({N-[(2S)-2-Ammonio-4-methylpentanoyl]glycyl}amino)-3-phenylpropanoate structure](https://static.chemtradehub.com/structs/429/4294-25-1-0842.webp "(2S)-2-({N-[(2S)-2-Ammonio-4-methylpentanoyl]glycyl}amino)-3-phenylpropanoate structure")
(2S)-2-({N-[(2S)-2-Ammonio-4-methylpentanoyl]glycyl}amino)-3-phenylpropanoate
CAS Number:
4294-25-1
Molecular Formula:
C17H25N3O4
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