Rh(iii)-Catalyzed C–H allylation/annulative Markovnikov addition with 5-methylene-1,3-dioxan-2-one: formation of isoquinolinones containing a C3 quaternary centre
Literature Information
Publication Date
2021-10-05
DOI
10.1039/D1QO01232K
Impact Factor
5.281
Authors
Xinghua Li, Jintong Bai, Zhaoyu Huang, Minhai Yin, Jiarong Sheng
View Original
Abstract
The Rh(III)-catalyzed synthesis of isoquinolinones containing a C3 quaternary centre via a tandem C–H allylation/annulative Markovinkov addition reaction has been achieved. This method employing a single Rh(III) complex as the catalyst tolerated various functional groups, and was applicable to late-stage diversification of N-methoxyamides derived from steroids and adapalene. By applying the protocol as the key step, US28 inverse agonist analogs were conveniently synthesized.
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Organic Chemistry Frontiers
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