One pot synthesis of isocyano-containing, densely functionalised gem-difluoroalkenes from α-trifluoromethyl alkenes, alkyl halides and TosMIC
Literature Information
Publication Date
2021-08-26
DOI
10.1039/D1QO01024G
Impact Factor
5.281
Authors
Hongtai Huang, Junyu Chen, Yubo Jiang, Tiebo Xiao
View Original
Abstract
Here we report a base-promoted one-pot, three-component reaction of TosMIC with α-trifluoromethyl alkenes and alkyl halides for the synthesis of isocyano- containing, densely functionalised gem-difluoroalkenes. This protocol displays broad scope and excellent functional group compatibility. Moreover, we demonstrate that the products can be used as precursors to various medicinally relevant fluorine- or heterocycle-containing compouds.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![4-[(2-Fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-3-cinnolinecarboxamide structure](https://static.chemtradehub.com/structs/104/1041852-85-0-fb1c.webp "4-[(2-Fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-3-cinnolinecarboxamide structure")
4-[(2-Fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-3-cinnolinecarboxamide
CAS Number:
1041852-85-0
Molecular Formula:
C23H27FN6O3
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